During the time of the Crusades, the area was controlled by the Armenian Kingdom of Cilicia. The Seljuk invasion of Armenia was followed by an exodus of Armenians southwards, and in 1080, Ruben, a relative of the last king of Ani, founded in the heart of the Cilician Taurus a small principality, which gradually expanded into the kingdom of Lesser Armenia or Armenia Minor. This Christian kingdom, surrounded by Moslem states, hostile to the Byzantines, giving valuable support to the crusaders, and trading with the great commercial cities of Italy had a stormy existence of about 300 years. Gosdantin (1095-1100) assisted the crusaders on their march to Antioch, and was created knight and marquis. Thoros I (1100-1123), in alliance with the Christian princes of Syria, waged successful war against the Byzantines and Seljuk Turks. Levond II (Leo the Great (r. 1187-1219)), extended the kingdom beyond Mount Taurus and established the capital at Sis. He assisted the crusaders, was crowned King by the Archbishop of Mainz, and married one of the Lusignans of the crusader kingdom Cyprus.
Haithon I (r. 1226-1270) made an alliance with the Mongols, who, before their adoption of Islam, protected his kingdom from the Mamelukes of Egypt. When Levond V died (1342), John of Lusignan was crowned king as Gosdantin IV; but he and his successors alienated the native Armenians by attempting to make them conform to the Roman Church, and by giving all posts of honor to Latins, until at last the kingdom, a prey to internal dissensions, succumbed (1375) to the attacks of the Egyptian mamelukes.
Cilicia Trachea was conquered by the Ottomans in the 15th century, but Cilicia Pedias remained independent until 1515.